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KMID : 0923620230230010008
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Immune Network
2023 Volume.23 No. 1 p.8 ~ p.8
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Human CD8+ T-Cell Populations That Express Natural Killer Receptors
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Koh June-Young
Kim Dong-Uk
Moon Bae-Hyeon
Shin Eui-Cheol
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Abstract
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CD8+ T cells are activated by TCRs that recognize specific cognate Ags, while NK-cell activation is regulated by a balance between signals from germline-encoded activating and inhibitory NK receptors. Through these different processes of Ag recognition, CD8+ T cells and NK cells play distinct roles as adaptive and innate immune cells, respectively. However, some human CD8+ T cells have been found to express activating or inhibitory NK receptors. CD8+ T-cell populations expressing NK receptors straddle the innate-adaptive boundary with their innate-like features. Recent breakthrough technical advances in multi-omics analysis have enabled elucidation of the unique immunologic characteristics of these populations. However, studies have not yet fully clarified the heterogeneity and immunological characteristics of each CD8+ T-cell population expressing NK receptors. Here we aimed to review the current knowledge of various CD8+ T-cell populations expressing NK receptors, and to pave the way for delineating the landscape and identifying the various roles of these T-cell populations.
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KEYWORD
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CD8-Positive T-Lymphocytes, Natural Killer Cell Receptors, CD56 Antigen, Receptors, KIR, NKG2A Receptor, NKG2C Receptor
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